We first optimized cell models of persistent infection in human hepatocyte cell lines HepG2 and Huh7 and primary mouse hepatocytes (PMH). Here, we examine whether this long-term infection alters hepatocyte defense pathways, which may be instrumental for bacterial persistence. However, recent evidence suggests that during long-term infection of hepatocytes, a subpopulation of Listeria may escape eradication by entering a persistence phase in intracellular vacuoles. After the intestinal phase of infection, the liver plays a central role in the clearance of this pathogen through its important functions in immunity. Listeria monocytogenes causes severe foodborne illness in pregnant women and immunocompromised individuals.

4Terry Fox Cancer Research Laboratories, Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St.3UniversitГ© Paris-Saclay, Institut de Biologie IntГ©grative de la Cellule, CEA, CNRS UMR 9198, UniversitГ© Paris-Sud, Gif-sur-Yvette, France.2UniversitГ© Paris-Saclay, INRAE, Virologie et Immunologie MolГ©culaires, Jouy-en-Josas, France.1UniversitГ© Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France.Natalie Descoeudres 1, Luc Jouneau 2, CГ©line Henry 1, Kevin Gorrichon 3, AurГ©lie DerrГ©-Bobillot 1, Pascale Serror 1, Laura Lee Gillespie 4, Cristel Archambaud 1, Alessandro Pagliuso 1 and HГ©lГЁne Bierne 1*

Geo 5 gillepsie notes week 8